Nikeforos Bryennios names "maiori natu Isaacio…iunior Ioannes" as the two sons of "Comneni Manuelis". His parentage is confirmed by the Alexeiad which describes Emperor Isaakios Komnenos as brother-in-law of Anna Dalassena, an earlier passage naming him Ioannes.
Patrikios. Skylitzes records that Emperor Isaakios created "Joannem fratrem et Catacalon Combustum curopalatas" and "fratrem suum magnum domesticum" after his accession, in 1057. His brother abdicated in his favour 25 Dec 1059, but Ioannes refused the throne.
He became a monk as IOANNES. Nikeforos Bryennios records the death of "Ioannes...Comnenus curopalates" which occurred "nec multo post" the death of Emperor Konstantinos X Doukas [dated to 23 May 1067]. The typikon of Theotokos Kecharitomenes (dated to [1110]) provides for the commemoration 12 Jul of "feu kyr Jean, le...beau-père de ma Majesté". The list of obituaries of the monastery of Christ Philanthropos, founded by Empress Eirene Doukas, records the death 12 Jul of "Ioannou monaxou kai patros tou basileos". 1